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1

ChemInform Abstract: Unsymmetrical Cyclic Ureas as HIV-1 Protease Inhibitors: Novel Biaryl Indazoles as P2/P2′ Substituents.

Mona Patel, James D. Rodgers, Robert J. McHugh Jr., Barry L. Johnson, Beverly C. Cordova, Ronald M. Klabe, Lee T. Bacheler, Susan Erickson-Viitanen, Soo S. Ko

Journal:

Année:

2000

Fichier:

PDF, 33 KB

2000

2

ChemInform Abstract: Synthesis and Evaluation of Efavirenz (Sustiva) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain.

Anthony J. Cocuzza, Dennis R. Chidester, Beverly C. Cordova, Susan Jeffrey, Rodney L. Parsons, Lee T. Bacheler, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 34 KB

english, 2001

3

ChemInform Abstract: Synthesis and Evaluation of Novel Quinolinones as HIV-1 Reverse Transcriptase Inhibitors.

Mona Patel, Robert J. McHugh Jr., Beverly C. Cordova, Ronald M. Klabe, Lee T. Bacheler, Susan Erickson-Viitanen, James D. Rodgers

Journal:

Année:

2001

Fichier:

PDF, 33 KB

2001

4

A comparison of HIV-1 drug susceptibility as provided by conventional phenotyping and by a phenotype prediction tool based on viral genotype

Margriet Van Houtte, Gaston Picchio, Koen Van Der Borght, Theresa Pattery, Pierre Lecocq, Lee T. Bacheler

Journal:

Journal of Medical Virology

Année:

2009

Langue:

english

Fichier:

PDF, 276 KB

english, 2009

5

A bis-[N-3-(1-hydroxy-1-methyl-ethyl)-benzyl)-cyclic urea as a HIV protease inhibitor

Wendell W. Wilkerson, Andrea Y. Hollis, Walter W. Cheatham, Gilbert N. Lam, Susan Erickson-Viitanen, Lee Bacheler, Beverly C. Cordova, Ronald M. Klabe, James L. Meek

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 364 KB

english, 1995

6

Synthesis of (+)-biotin derivatives as HIV-1 protease inhibitors

Qi Han, Jennifer Lafontaine, Lee T. Bacheler, Marlene M. Rayner, Ronald M. Klabe, Susan Erickson-Viitanen, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 212 KB

english, 1996

7

Synthesis and Evaluation of Efavirenz (SustivaTM) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain

Anthony J. Cocuzza, Dennis R. Chidester, Beverly C. Cordova, Susan Jeffrey, Rodney L. Parsons, Lee T. Bacheler, Susan Erickson-Viitanen, George L. Trainor, Soo S. Ko

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 102 KB

english, 2001

8

4,1-Benzoxazepinone analogues of efavirenz (Sustiva™) as HIV-1 reverse transcriptase inhibitors

Anthony J. Cocuzza, Dennis R. Chidester, Beverly C. Cordova, Ronald M. Klabe, Susan Jeffrey, Sharon Diamond, Carolyn A. Weigelt, Soo S. Ko, Lee T. Bacheler, Susan K. Erickson-Viitanen, James D. Rodger

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 130 KB

english, 2001

9

Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

Mona Patel, Robert J McHugh Jr., Beverly C Cordova, Ronald M Klabe, Lee T Bacheler, Susan Erickson-Viitanen, James D Rodgers

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 121 KB

english, 2001

10

Functionalized aliphatic P2/P2′ analogs of HIV-1 protease inhibitor DMP323

Joanne M. Smallheer, Robert J. McHugh, Chong-Hwan Chang, Robert F. Kaltenbach III, Tabitha V. Worley, Ronald M. Klabe, Lee T. Bacheler, Marlene M. Rayner, Susan Erickson-Viitanen, Steven P. Seitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 432 KB

english, 1997

11

The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1′ residues

Mona Patel, Lee T. Bacheler, Marlene M. Rayner, Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, Steven P. Seitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 264 KB

english, 1998

12

Potent cyclic urea HIV protease inhibitors with 3-aminoindazole P2/P2′ groups

James D. Rodgers, Barry L. Johnson, Wang Haisheng, Susan Erickson-Viitanen, Ronald M. Klabe, Lee Bacheler, Beverly C. Cordova, Chong-Hwan Chang

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 251 KB

english, 1998

13

The synthesis of symmetrical and unsymmetrical P1/P1′ cyclic ureas as HIV protease inhibitors

Mona Patel, Robert F. Kaltenbach III, David A. Nugiel, Robert J. McHugh Jr., Prabhakar K. Jadhav, Lee T. Bacheler, Beverly C. Cordova, Ronald M. Klabe, Susan Erickson-Viitanen, Sena Garber, Carol Reid

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 264 KB

english, 1998

14

Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: Novel biaryl indazoles as P2/P2′ substituents

Mona Patel, James D. Rodgers, Robert J. McHugh Jr., Barry L. Johnson, Beverly C. Cordova, Ronald M. Klabe, Lee T. Bacheler, Susan Erickson-Viitanen, Soo S. Ko

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 206 KB

english, 1999

15

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors

James D. Rodgers, Patrick Y.S. Lam, Barry L. Johnson, Haisheng Wang, Soo S. Ko, Steven P. Seitz, George L. Trainor, Paul S. Anderson, Ronald M. Klabe, Lee T. Bacheler, Beverly Cordova, Sena Garber, Ca

Journal:

Chemistry & Biology

Année:

1998

Langue:

english

Fichier:

PDF, 2.46 MB

english, 1998

16

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors

James D. Rodgers, Patrick Y.S. Lam, Barry L. Johnson, Haisheng Wang, Soo S. Ko, Steven P. Seitz, George L. Trainor, Paul S. Anderson, Ronald M. Klabe, Lee T. Bacheler, Beverly Cordova, Sena Garber, Ca

Journal:

Chemistry & Biology

Année:

1998

Fichier:

PDF, 33 KB

1998

17

Cross-validated stepwise regression for identification of novel non-nucleoside reverse transcriptase inhibitor resistance associated mutations

Koen Van der Borght, Elke Van Craenenbroeck, Pierre Lecocq, Margriet Van Houtte, Barbara Van Kerckhove, Lee Bacheler, Geert Verbeke, Herman van Vlijmen

Journal:

BMC Bioinformatics

Année:

2011

Langue:

english

Fichier:

PDF, 346 KB

english, 2011

18

Synthesis, antiviral activity and pharmacokinetics of P1/P1′ substituted 3-aminoindazole cyclic urea HIV protease inhibitors

Robert F Kaltenbach III, Mona Patel, Robert E Waltermire, Gregory D Harris, Benjamin R.P Stone, Ronald M Klabe, Sena Garber, Lee T Bacheler, Beverly C Cordova, Kelly Logue, Matthew R Wright, Susan Eri

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 126 KB

english, 2003

19

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

C. Nicholas Hodge, Paul E. Aldrich, Lee T. Bacheler, Chong-Hwan Chang, Charles J. Eyermann, Sena Garber, Mary Grubb, David A. Jackson, Prabharkar K. Jadhav, Bruce Korant, Patrick Y.S. Lam, Michael B.

Journal:

Chemistry & Biology

Année:

1996

Langue:

english

Fichier:

PDF, 2.85 MB

english, 1996

20

Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes

Fu-Kuen Lin, Chi-Hwei Lin, Chuan Chu Chou, Kenneth Chen, Hsieng S. Lu, William Bacheller, Charles Herrera, Ted Jones, Julie Chao, Lee Chao

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

1993

Langue:

english

Fichier:

PDF, 289 KB

english, 1993

21

Clinical cut-offs for HIV-1 phenotypic resistance estimates: Update based on recent pivotal clinical trial data and a revised approach to viral mixtures

Bart Winters, Elke Van Craenenbroeck, Koen Van der Borght, Pierre Lecocq, Jorge Villacian, Lee Bacheler

Journal:

Journal of Virological Methods

Année:

2009

Langue:

english

Fichier:

PDF, 509 KB

english, 2009

22

Inhibition of Clinically Relevant Mutant Variants of HIV-1 by Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors

Corbett, Jeffrey W., Ko, Soo S., Rodgers, James D., Gearhart, Lisa A., Magnus, Nicholas A., Bacheler, Lee T., Diamond, Sharon, Jeffrey, Susan, Klabe, Ronald M., Cordova, Beverly C.

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 175 KB

english, 2000

23

Density-dependent habitat use and growth of an estuarine fish

Bacheler, Nathan M., Buckel, Jeffrey A., Paramore, Lee M., Rochet, Marie-Joëlle

Journal:

Canadian Journal of Fisheries and Aquatic Sciences

Année:

2012

Fichier:

PDF, 1.09 MB

2012

24

Using generalized linear models to estimate selectivity from short-term recoveries of tagged red drum Sciaenops ocellatus: Effects of gear, fate, and regulation period

Nathan M. Bacheler, Joseph E. Hightower, Summer M. Burdick, Lee M. Paramore, Jeffrey A. Buckel, Kenneth H. Pollock

Journal:

Fisheries Research

Année:

2010

Langue:

english

Fichier:

PDF, 949 KB

english, 2010

25

Resistance to non-nucleoside inhibitors of HIV-1 reverse transcriptase

Lee T. Bacheler

Journal:

Drug Resistance Updates

Année:

1999

Langue:

english

Fichier:

PDF, 254 KB

english, 1999

26

Cyclic Urea Amides: HIV-1 Protease Inhibitors with Low Nanomolar Potency against both Wild Type and Protease Inhibitor Resistant Mutants of HIV

Jadhav, Prabhakar K., Ala, Paul, Woerner, Francis J., Chang, Chong-Hwan, Garber, Sena S., Anton, Elizabeth D., Bacheler, Lee T.

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 327 KB

english, 1997

27

Molecular clones of endogenous murine leukemia virus-related DNA sequences from Balb/c mice: Characterization of integration sites

Lee T. Bacheler

Journal:

Année:

1984

Langue:

english

Fichier:

PDF, 3.67 MB

english, 1984

28

Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies

Jadhav, Prabhakar K., Woerner, Francis J., Lam, Patrick Y. S., Hodge, C. Nicholas, Eyermann, Charles J., Man, Hon-Wah, Daneker, Wayne F., Bacheler, Lee T., Rayner, Marlene M., Meek, James L., Erickson

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 212 KB

english, 1998

29

Improved P1/P1‘ Substituents for Cyclic Urea Based HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationship, and X-ray Crystal Structure Analysis

Nugiel, David A., Jacobs, Kim, Cornelius, Lyndon, Chang, Chong-Hwan, Jadhav, Prabhakar K., Holler, Edward R., Klabe, Ronald M., Bacheler, Lee T., Cordova, Beverly, Garber, Sena, Reid, Carol, Logue, Ke

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 302 KB

english, 1997

30

Nonsymmetric P2/P2‘ Cyclic Urea HIV Protease Inhibitors. Structure−Activity Relationship, Bioavailability, and Resistance Profile of Monoindazole-Substituted P2 Analogues

De Lucca, George V., Kim, Ui T., Liang, Jing, Cordova, Beverly, Klabe, Ronald M., Garber, Sena, Bacheler, Lee T., Lam, Gilbert N., Wright, Matthew R., Logue, Kelly A., Erickson-Viitanen, Susan, Ko, So

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 242 KB

english, 1998

31

In vitro polyoma DNA synthesis: Asymmetry of short DNA chains

Hunter, Tony, Francke, Bertold, Bacheler, Lee

Journal:

Année:

1977

Langue:

english

Fichier:

PDF, 864 KB

english, 1977

32

4960109 Multi-purpose temperature sensing probe for hyperthermia therapy

Hunter, Tony, Francke, Bertold, Bacheler, Lee

Journal:

Ultrasound in Medicine & Biology

Année:

1992

Langue:

english

Fichier:

PDF, 87 KB

english, 1992

33

Cloning and characterization of a rat-specific repetitive DNA sequence

Shore, Scott K., Bacheler, Lee T., Kimball de Riel, J., Barrows, Louis R., Lynch, Mark

Journal:

Année:

1986

Langue:

english

Fichier:

PDF, 562 KB

english, 1986

34

Isolation of proteins from commercial beet sugar preparations

Potter, Robert L., Bacheller, John D., Chassy, Lee M., Mansell, Richard L.

Journal:

Journal of Agricultural and Food Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 2.19 MB

english, 1990

35

Transcription of isolated mouse liver chromatin

Bacheler, Lee T., Smith, Kirby D.

Journal:

Année:

1976

Langue:

english

Fichier:

PDF, 2.02 MB

english, 1976

36

Resistance to HIV Protease Inhibitors: A Comparison of Enzyme Inhibition and Antiviral Potency

Klabe, Ronald M., Bacheler, Lee T., Ala, Paul J., Erickson-Viitanen, Susan, Meek, James L.

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 234 KB

english, 1998

37

Recruitment of Juvenile Red Drum in North Carolina: Spatiotemporal Patterns of Year-Class Strength and Validation of a Seine Survey

Bacheler, Nathan M., Paramore, Lee M., Buckel, Jeffrey A., Scharf, Frederick S.

Journal:

North American Journal of Fisheries Management

Année:

2008

Langue:

english

Fichier:

PDF, 275 KB

english, 2008

38

A combined telemetry – tag return approach to estimate fishing and natural mortality rates of an estuarine fish

Jech, Josef Michael, Bacheler, Nathan M., Buckel, Jeffrey A., Hightower, Joseph E., Paramore, Lee M., Pollock, Kenneth H.

Journal:

Canadian Journal of Fisheries and Aquatic Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2009

39

A 21-Base Pair Insertion/Duplication at Codon 69 of the HIV Type 1 Reverse Transcriptase in a Patient Undergoing Multiple Nucleoside Therapy

Harrigan, P. Richard, Mo, Theresa, Hirsch, Jennifer, Brumme, Zabrina L., McKenna, Paula, Bacheler, Lee

Journal:

AIDS Research and Human Retroviruses

Année:

2007

Langue:

english

Fichier:

PDF, 72 KB

english, 2007

40

HIV-1 Neutralizing Monoclonal Antibodies Induced by a Synthetic Peptide

DURDA, PAUL J., BACHELER, LEE, CLAPHAM, PAUL, JENOSKI, ANNA M., LEECE, BARBARA, MATTHEWS, THOMAS J., McKNIGHT, AINE, POMERANTZ, ROGER, RAYNER, MARLENE, WEINHOLD, KENT J.

Journal:

AIDS Research and Human Retroviruses

Année:

1990

Langue:

english

Fichier:

PDF, 3.29 MB

english, 1990

41

Human Chromosome-Dependent and -Independent Pathways for HIV-2 Trans-Activation

HART, CLYDE E., WESTHAFER, MARK A., GALPHIN, JUDITH C., OU, CHIN-YIH, BACHELER, LEE T., PETTEWAY, STEVEN R., WASMUTH, JOHN J., CHEN, IRVIN S. Y., SCHOCHETMAN, GERALD

Journal:

AIDS Research and Human Retroviruses

Année:

1991

Langue:

english

Fichier:

PDF, 792 KB

english, 1991

42

Stable Indicator Cell Lines Exhibiting HIV-1 tat Function

BACHELER, LEE T., STREHL, LAURIE L., NEUBAUER, RUSSELL H., PETTEWAY, STEPHEN R., FERGUSON, BLAIR Q.

Journal:

AIDS Research and Human Retroviruses

Année:

1989

Langue:

english

Fichier:

PDF, 442 KB

english, 1989

43

HIV Drug Resistance Tests: An Update on Methods for Calculating Phenotypic Fold Change from a Viral Genotype

Bellosillo, Nobel A., Bacheler, Lee, Villacian, Jorge

Journal:

Clinical Infectious Diseases

Année:

2009

Langue:

english

Fichier:

PDF, 142 KB

english, 2009

44

Resistance and Virological Response Analyses in a Three Initial Treatment Strategy Trial: A Substudy of the INITIO Trial

Descamps, Diane, Chazallon, Corine, Loveday, Clive, Bacheler, Lee, Goodall, Ruth, Yéni, Patrick, Cooper, David A., Babiker, Abdel, Aboulker, Jean-Pierre, Brun-Vézinet, Francoise

Journal:

HIV Clinical Trials

Année:

2009

Langue:

english

Fichier:

PDF, 368 KB

english, 2009

45

Additional HIV-1 mutation patterns associated with reduced phenotypic susceptibility to etravirine in clinical samples

Kagan, Ron M, Sista, Prakash, Pattery, Theresa, Bacheler, Lee, Schwab, Dale A

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 316 KB

english, 2009

46

Protease mutation M89I/V is linked to therapy failure in patients infected with the HIV-1 non-B subtypes C, F or G

Abecasis, Ana Barroso, Deforche, Koen, Snoeck, Joke, Bacheler, Lee T, McKenna, Paula, Carvalho, Ana Patrícia, Gomes, Perpétua, Camacho, Ricardo Jorge, Vandamme, Anne-Mieke

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 97 KB

english, 2006

47

Evaluation of cutpoints for phenotypic hypersusceptibility to efavirenz

Bosch, Ronald J, Downey, Gerald F, Katzenstein, David A, Hellmann, Nicholas, Bacheler, Lee, Albrecht, Mary A, Study, for theACTG364

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 94 KB

english, 2003

48

Rare mutations at codon 103 of HIV-1 reverse transcriptase can confer resistance to non-nucleoside reverse transcriptase inhibitors

Harrigan, P Richard, Mo, Theresa, Wynhoven, Brian, Hirsch, Jennifer, Brumme, Zabrina, McKenna, Paula, Pattery, Theresa, Vingerhoets, Johan, Bacheler, Lee T

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 166 KB

english, 2005

49

Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs

Katzenstein, David A, Bosch, Ronald J, Hellmann, Nicholas, Wang, Nan, Bacheler, Lee, Albrecht, Mary A

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 218 KB

english, 2003

50

A randomized trial of therapeutic drug monitoring of protease inhibitors in antiretroviral-experienced, HIV-1-infected patients

Demeter, Lisa M, Jiang, Hongyu, Mukherjee, A Lisa, Morse, Gene D, DiFrancesco, Robin, DiCenzo, Robert, Dykes, Carrie, Sista, Prakash, Bacheler, Lee, Klingman, Karin, Rinehart, Alex, Albrecht, Mary

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 219 KB

english, 2009